A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos
A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos
复制标题
离子液体与敌敌畏之间毒性相互作用的新型直接均分射线设计（EquRay）程序
DOI：
10.1007/s11356-010-0419-7
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发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Deng, Fu-Cai
中科院分区：
文献类型：
--
作者：
Dou, Rong-Ni;Liu, Shu-Shen;Deng, Fu-Cai
背景、目标和范围 污染物总是在环境中共存。确定和表征化学品之间的相互作用是一个重要问题。实验设计（ED）在评估相互作用方面发挥着重要作用。我们研究的主要目的是通过一种新的 ED 方法来测试和分析毒性相互作用。 材料和方法 提出了一种新的直接均分射线设计 (EquRay) 程序来有效、系统地测定二元混合物对青海弧菌-Q67 的毒性。这里，一种组分是离子液体、1-丁基-2,3-二甲基咪唑氯化物(IL1)、1-丁基溴化吡啶鎓(IL2)或N-己基吡啶鎓双(三氟甲基磺酰基)亚胺(IL3)，另一种组分是敌敌畏(DIC)。通过比较实验和加性模型以及三维偏差响应面(DRS)分析来评价毒性相互作用。结果选择CA作为参考模型，二元混合物的作用小于加性(拮抗)作用。大多数偏差发生在 DRS 的中心部分，其中 IL1-DIC 和 IL2-DIC 混合物的 dCA（CA 偏差）值在 -15% 和 -26% 之间，而 IL3 和 DIC 的 dCA（CA 偏差）值在 -10% 和 -15% 之间。选择 IA 作为加和模型，IL1-DIC 和 IL2-DIC 混合物表现出小于加和（拮抗）作用，而 IL3-DIC 表现出加成作用，并且 dIA 的绝对值（与 IA 的偏差）小于 10%。 结论 本研究开发了一种新的 EquRay 程序，EquRay 可以为我们提供有关不同浓度区域、不同混合比例的二元混合物成分（例如 DIC 和 IL）之间的毒性相互作用的信息。
Background, aim and scope Pollutants always co-exist in the environment. Determining and characterizing the interaction among chemicals is an important issue. Experimental designs (ED) play an important role in evaluating the interactions. The main aim of our study is to provide the test and analysis of the toxicity interaction with a novel ED method.Materials and methods A novel direct equipartition ray design (EquRay) procedure was proposed to effectively and systematically determine the toxicities of binary mixtures on Vibrio qinghaiensis sp.-Q67. Here, one component is ionic liquid, 1-butyl-2,3-dimethylimidazolium chloride (IL1), 1-butylpyridinium bromide (IL2) or N-hexylpyridinium bis(trifluoromethylsulfonyl)imide (IL3), and another is dichlorvos (DIC). The toxicity interaction was evaluated by comparing experiment and additive model together with three-dimension deviation response surface (DRS) analysis.Result Selecting CA as a reference model, the binary mixtures exerted less than additive (antagonism). Most of the deviations occurred in the centre portion of the DRS where the dCA (deviation from CA) values are between -15% and -26% for IL1-DIC and IL2-DIC mixtures and -10% and -15% for IL3 and DIC. Selecting IA as a additive model, IL1-DIC and IL2-DIC mixtures exhibited less than additive (antagonism) while IL3-DIC displayed an addition action and the absolute values of dIAs (deviation from IA) were less than 10%.Conclusion A novel EquRay procedure was developed in this study and the EquRay can provide us with the information about the toxicity interaction between binary mixture components (such as DIC and IL) in different concentration regions across different mixture ratios.