The role of particle physico-chemical properties in pulmonary drug delivery for tuberculosis therapy
The role of particle physico-chemical properties in pulmonary drug delivery for tuberculosis therapy
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DOI：
10.3109/02652048.2014.932029
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发表时间：
2014-01-01
影响因子：
3.9
通讯作者：
Hickey, Anthony J.
中科院分区：
文献类型：
--
作者：
Mortensen, Ninell P.;Durham, Phillip;Hickey, Anthony J.
人们对使用吸入气雾剂药物疗法治疗结核病 (TB) 越来越感兴趣。已采用多种制备颗粒的方法，包括喷雾干燥、溶剂蒸发、乳液和磷脂方法来产生微粒、大聚集纳米颗粒、固体脂质纳米颗粒和脂质体。这些方法中的每一种都涉及使用不同比例的添加剂来帮助颗粒形成或实现重要的物理化学性质，例如易于分散。虽然这些方法都有优点，但它们的实际价值受到剂量和作为气雾剂递送方式以实现治疗效果的限制的限制。本文对多种方法进行了回顾，并将其置于治疗结核病的有效气雾剂输送系统需求的背景下，作为选择适当的赋形剂、工艺和输送策略以支持产品开发活动的指南。
There is increasing interest in the use of inhaled aerosol drug therapy for the treatment of tuberculosis (TB). A number of methods of preparation of particles have been employed including spray drying, solvent evaporation, emulsion and phospholipid methods to create microparticles, macroaggregated nanoparticles, solid lipid nanoparticles and liposomes. Each of these methods involves the use of different proportions of additives to aid in the particle formation or to achieve important physico-chemical properties such as ease of dispersion. While these approaches all have merit their practical value is limited by constraints on dose and means of delivery as an aerosol in order to achieve a therapeutic effect. A review of a number of approaches is presented and placed in the context of the need for effective aerosol delivery systems for the treatment of TB as a guide to selection of appropriate excipients, processes and delivery strategies to support product development activities.