Adherence of Bordetella pertussis to human respiratory epithelial cells.
Adherence of Bordetella pertussis to human respiratory epithelial cells.
复制标题
百日咳博德特氏菌对人呼吸道上皮细胞的粘附。
DOI：
10.1093/infdis/148.1.125
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Hendley,JO
中科院分区：
文献类型：
--
作者：
Tuomanen,EI;Hendley,JO
百日咳博德特氏菌对纤毛呼吸道粘膜的粘附在百日咳的发病机制中很重要。使用通过支气管镜检查刷牙获得的细胞来研究百日咳博德特氏菌对人呼吸道上皮细胞的粘附。百日咳博德特氏菌仅附着于纤毛细胞的纤毛簇。当浓度为 2 × 109/ml 的细菌与纤毛细胞一起孵育时，每个细胞附着 5.0 ± 0.3 个生物体，平均值±SEM。通过电子显微镜检查发现，生物体通过直接附着和通过细菌与纤毛之间的细丝粘附在纤毛上。百日咳博德特氏菌粘附于纤毛簇的特异性可以解释该生物体感染人类气管支气管粘膜的独特能力。
Adherence ofBordetella pertussisto ciliated respiratory tract mucosa is important in the pathogenesis of whooping cough. The adherence ofB pertussisto human respiratory epithelial cells was investigated using cells obtained by brushing at bronchoscopy.B pertussisattached exclusively to the ciliary tufts of ciliated cells. A mean ± SEM of 5.0 ± 0.3 organisms attached per cell when bacteria in a concentration of 2 × 109/ml were incubated with ciliated cells. Organisms examined by electron microscopy were found to adhere to the cilia both by direct apposition and by filaments coursing between bacteria and cilia. The specificity of the adherence ofB pertussisto ciliary tufts may explain the unique ability of this organism to infect the human tracheobronchial mucosa.