COMPLETION OF MOUSE EMBRYOGENESIS REQUIRES BOTH THE MATERNAL AND PATERNAL GENOMES
COMPLETION OF MOUSE EMBRYOGENESIS REQUIRES BOTH THE MATERNAL AND PATERNAL GENOMES
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DOI：
10.1016/0092-8674(84)90313-1
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发表时间：
1984-01-01
期刊：
影响因子：
64.5
通讯作者：
SOLTER, D
中科院分区：
文献类型：
--
作者：
MCGRATH, J;SOLTER, D
Transplantation of pronuclei between 1-cell-stage embryos was used to construct diploid mouse embryos with 2 female pronuclei (biparental gynogenomes) or 2 male pronuclei (biparental androgenomes). The ability of these embryos to develop to term was compared with control nuclear-transplant embryos in which the male or the female pronucleus was replaced with an isoparental pronucleus from another embryo. Diploid biparental gynogenetic and androgenetic embryos do not complete normal embryogenesis, whereas control nuclear transplant embryos do. The maternal and paternal contributions to the embryonic genome in mammals are not equivalent and that a diploid genome derived from only 1 of 2 parental sexes is incapable of supporting complete embryogenesis.
