Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde.
Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde.
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DOI：
10.7554/elife.63177
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发表时间：
2021-01-04
期刊：
影响因子：
7.7
通讯作者：
Goldberg A
中科院分区：
文献类型：
--
作者：
Hamid I;Korunes KL;Beleza S;Goldberg A
在过去的几百年到几千年里，人类经历了大规模的迁徙，使自己暴露在新的环境和选择压力下。然而，人类正在进行或最近的选择的证据很难发现。这些迁移也导致了以前分离的种群之间的基因流动。这些最近混合的种群为研究人类的快速进化提供了独特的机会。开发方法的基础上分布的地方血统，我们证明，这种遗传交换促进了可检测的适应疟疾寄生虫在混合人口的卡波佛得角在过去的20代。我们估计，选择系数约为0.08，这是人类中推断的最高值之一。值得注意的是，我们表明，这种强选择在一个单一的基因座可能会影响模式的祖先全基因组，潜在的偏见人口推断。我们的研究提供了人类在历史时间尺度上适应的证据。
Humans have undergone large migrations over the past hundreds to thousands of years, exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing or recent selection in humans is difficult to detect. Many of these migrations also resulted in gene flow between previously separated populations. These recently admixed populations provide unique opportunities to study rapid evolution in humans. Developing methods based on distributions of local ancestry, we demonstrate that this sort of genetic exchange has facilitated detectable adaptation to a malaria parasite in the admixed population of Cabo Verde within the last ~20 generations. We estimate that the selection coefficient is approximately 0.08, one of the highest inferred in humans. Notably, we show that this strong selection at a single locus has likely affected patterns of ancestry genome-wide, potentially biasing demographic inference. Our study provides evidence of adaptation in a human population on historical timescales.