Effects of the menopausal transition on energy expenditure: a MONET Group Study.
Effects of the menopausal transition on energy expenditure: a MONET Group Study.
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DOI：
10.1038/ejcn.2013.33
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发表时间：
2013-04
影响因子：
4.7
通讯作者：
Doucet E
中科院分区：
文献类型：
--
作者：
Duval K;Prud'homme D;Rabasa-Lhoret R;Strychar I;Brochu M;Lavoie JM;Doucet E
影响绝经过渡期体重增加的因素尚未完全了解。本研究的目的是调查绝经过渡期能量消耗（EE）的变化。对102名绝经前女性（年龄：49.9 ± 1.9岁; BMI：23.3 ± 2.2 kg/m2）进行了5年随访。每年测量身体成分（DXA）、体力活动EE（加速度计）、静息EE和食物热效应（间接量热法）。绝经后妇女总EE随时间显著下降（P < 0.05），这主要是由于体力活动EE减少（P < 0.05）。尽管绝经后妇女的平均静息EE随时间保持稳定，但在5年期间，在第5年处于绝经过渡期的妇女中观察到显著增加（P < 0.05）。在绝经过渡期，中等强度体力活动时间减少，久坐体力活动时间增加（P < 0.05）。这些结果表明，绝经过渡期伴随着EE下降，主要特征是体力活动EE减少和向久坐不动的生活方式转变。
Factors that influence weight gain during the menopausal transition are not fully understood. The purpose of this study was to investigate changes in energy expenditure (EE) across the menopausal transition. One hundred and two premenopausal women (age: 49.9 ± 1.9 yrs; BMI: 23.3 ± 2.2 kg/m2) were followed for 5 years. Body composition (DXA), physical activity EE (accelerometer), resting EE and thermic effect of food (indirect calorimetry) were measured annually. Total EE decreased significantly over time in postmenopausal women (P < 0.05), which was mostly due to a decrease in physical activity EE (P < 0.05). Although average resting EE remained stable over time in postmenopausal women, a significant increase, over the 5-year period, was noted in women who were in the menopausal transition by year 5 (P < 0.05). Finally, the time spent in moderate physical activity decreased and the time spent in sedentary physical activity increased during the menopausal transition (P < 0.05). These results suggest that menopausal transition is accompanied with a decline in EE mainly characterized by a decrease in physical activity EE and a shift to a more sedentary lifestyle.