Role of chemokines in inflammation and immunoregulation
Role of chemokines in inflammation and immunoregulation
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DOI：
10.1385/ir:21:2-3:203
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发表时间：
2000-01-01
影响因子：
4.4
通讯作者：
Feng, LL
中科院分区：
文献类型：
--
作者：
Feng, LL
趋化因子首先注意到它们吸引和激活白细胞的能力，以及它们作为炎症介质的潜在作用。然而，新的数据表明，各种趋化因子可能在免疫系统内外发挥其他生物学作用。诱导型趋化因子主要参与炎症反应，并构成趋化因子家族的大部分。组成型趋化因子主要在次级淋巴器官和一些非淋巴器官中表达，它们在淋巴细胞归巢中起主要作用。扩展到炎症白细胞募集以外的领域的研究可能会给我们一个更完整的图片趋化因子的功能，它在淋巴和非淋巴组织中的调节，以及利用内源性趋化因子干预免疫和炎症反应的方法。
Chemokines are first noted for their ability to attract and activate leukocytes, as well as their potential role as mediators of inflammation. However, emerging data have shown that various chemokines may exert other biologic effects both inside and outside the immune system. Inducible chemokines participate primarily in inflammatory responses and comprise the bulk of the chemokine family. Constitutive chemokines are expressed primarily in secondary lymphoid organs and some nonlymphoid organs, where they play a major role in lymphocyte homing. Studies expanding to areas beyond inflammatory leukocyte recruitment will likely give us a more complete picture of chemokine function, its regulation in lymphoid and nonlymphoid tissues, and ways of utilizing endogenous chemokines to intervene with immune and inflammatory reactions.