Renal circulatory responses to general anaesthesia in the rabbit: studies using radioactive microspheres.
Renal circulatory responses to general anaesthesia in the rabbit: studies using radioactive microspheres.
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兔子全身麻醉的肾循环反应：使用放射性微球的研究。
DOI：
10.1042/cs0480061
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
J. Ledingham
中科院分区：
文献类型：
--
作者：
D. Warren;J. Ledingham
1.用放射性微球技术测定清醒兔及戊巴比妥钠、氯醛糖-氨基甲酸乙酯或乙醚麻醉后的肾总血流量及其皮质分布。2.戊巴比妥钠麻醉引起肾总血流量下降26%，皮质浅血流量下降26%，皮质深血流量下降24%。钠排泄率下降33%。3.氯醛糖-氨基甲酸酯复合麻醉对全肾或局部肾血流量无影响，对钠排泄无明显影响。4.乙醚麻醉对总肾血流量的影响不明显，但浅层皮质血流量下降13%，深层皮质血流量增加21%。尿钠排泄量下降65%。5.讨论了麻醉引起这些变化的可能机制。6.麻醉剂的作用可能会影响对已发表的关于肾循环控制机制的工作的解释。
1. Total renal blood flow and its cortical distribution were measured by the radioactive microsphere technique in conscious rabbits and after anaethesia with pentobarbitone, chloralose-urethane or ether. 2. Pentobarbitone anaesthesia caused a fall of 26% in total renal blood flow, of 26% in superficial cortical flow, and of 24% in deep cortical flow. Sodium excretion rate fell by 33%. 3. Chloralose-urethane anaesthesia caused no change in total or regional renal blood flow, or in sodium excretion. 4. Ether anaesthesia caused an insignificant fall in total renal blood flow, but superficial cortical flow fell by 13% and deep cortical flow rose by 21%. Urinary sodium excretion fell by 65%. 5. Possible mechanisms for these changes in response to anaesthesia are discussed. 6. The effects of anaesthetic agents may influence the interpretation of published work on control mechanisms in the renal circulation.