Cutting edge:: Heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo
Cutting edge:: Heat shock protein gp96 induces maturation and migration of CD11c+ cells in vivo
复制标题
DOI：
10.4049/jimmunol.165.11.6029
复制
发表时间：
2000-12-01
影响因子：
4.4
通讯作者：
Srivastava, PK
中科院分区：
文献类型：
--
作者：
Binder, RJ;Anderson, KM;Srivastava, PK
用热休克蛋白（HSP）gp 96而不是对照蛋白免疫小鼠，导致引流淋巴结（LN）增大5- 7倍，这是由于大量成熟的CD 11 c（+）细胞而不是T或B淋巴细胞在其中积聚所致。大小和细胞结构的增加是时间依赖性的;引流LN在注射后12和24小时之间达到其峰值大小，并在注射后48和72小时之间回归到其正常大小。这一观察揭示了HSP-APC相互作用的一个新方面，并增加了HSP-肽复合物异常高免疫原性的机制解释。
Immunization of mice with the heat shock protein (HSP) gp96 but not control proteins leads to 5- to 7-fold enlargement of draining lymph nodes (LNs) resulting from accumulation of large numbers of mature CD11c(+) cells, but not T or B lymphocytes in them. The increase in size and cellularity is time-dependent; the draining LNs reach their peak size between 12 and 24 h after injection and regress to their normal size between 48 and 72 h after injection, The increment is elicited specifically in the draining LN but not in other LNs. This observation uncovers a novel aspect of HSP-APC interaction and adds to the mechanistic explanation for the unusually high immunogenicity of HSP-peptide complexes.