The incentive sensitization theory of addiction: some current issues
The incentive sensitization theory of addiction: some current issues
复制标题
DOI：
10.1098/rstb.2008.0093
复制
发表时间：
2008-10-12
影响因子：
6.3
通讯作者：
Berridge, Kent C.
中科院分区：
文献类型：
--
作者：
Robinson, Terry E.;Berridge, Kent C.
我们提出了一个简短的概述成瘾的激励敏化理论。这假定成瘾主要是由药物引起的大脑中皮质边缘系统的敏感化引起的，该系统将激励显着性归因于奖励相关刺激。如果过度敏感，这些系统会导致对药物的病态激励动机（“想要”）。我们解决一些当前的问题，包括：什么是学习的激励敏感化和成瘾的作用？人类成瘾者会出现激励敏感化吗？动物成瘾样行为的发展是否与致敏有关？使用动物模型模拟成瘾症状的最佳方法是什么？最后，情感愉悦或戒断在成瘾中的作用是什么？
We present a brief overview of the incentive sensitization theory of addiction. This posits that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems that attribute incentive salience to reward-associated stimuli. If rendered hypersensitive, these systems cause pathological incentive motivation ('wanting') for drugs. We address some current questions including: what is the role of learning in incentive sensitization and addiction? Does incentive sensitization occur in human addicts? Is the development of addiction-like behaviour in animals associated with sensitization? What is the best way to model addiction symptoms using animal models? And, finally, what are the roles of affective pleasure or withdrawal in addiction?.