Enantioselective Organocatalytic Sulfenylation of beta-Naphthols
Enantioselective Organocatalytic Sulfenylation of beta-Naphthols
复制标题
β-萘酚的对映选择性有机催化磺酰化
DOI：
10.1021/acs.joc.8b00487
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发表时间：
2018
影响因子：
3.6
通讯作者：
Chen Jie
中科院分区：
文献类型：
--
作者：
Wang Jiao-Jiao;Yang Hui;Gou Bo-Bo;Zhou Ling;Chen Jie
以新合成的金鸡纳硫脲为催化剂，N-(芳硫基)丁二酰亚胺(或邻苯二甲酰亚胺)为亲电硫源，首次研究了β-萘酚的对映选择性磺化反应。在温和的反应条件下，通过脱芳构化反应合成了以S全取代立体中心为中心的不同对映体富集型萘酮。
An enantioselective sulfenylation of β-naphthols has been developed for the first time using a newly synthesized cinchona-derived thiourea as the catalyst andN-(arylthio) succinimide (or phthalimide) as an electrophilic sulfur source. Various enantioenriched naphthalenones with an S-containing all-substituted stereocenter were prepared via a dearomatization strategy under mild reaction conditions.