Serum cartilage metabolites as biomarkers of degenerative lumbar scoliosis
Serum cartilage metabolites as biomarkers of degenerative lumbar scoliosis
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DOI：
10.1002/jor.22067
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发表时间：
2012-08-01
影响因子：
2.8
通讯作者：
Matsumoto, Morio
中科院分区：
文献类型：
--
作者：
Hosogane, Naobumi;Watanabe, Kota;Matsumoto, Morio
一些生物标志物已经被用来评估四肢关节的骨关节炎。在这里，我们评估了血清软骨代谢产物作为退行性腰椎侧凸(DLS)生物标志物的应用。将52例Cobb角为10°的DLS患者与19例对照组进行比较。测定血清透明质酸(HA)、硫酸角蛋白(KS)、软骨低聚基质蛋白(COMP)、II型胶原裂解酶(C2C)和II型前胶原C肽(CPII)水平。血清KS(DLS1.20+/-0.44mU/mlvs对照组0.98+/-0.33mU/ml)、CPII(DLS1905.1+/-948.2 ng/mlvs.对照组1223.6+/-884.4 ng/ml)和C2C(DLS219.1+/-59.2ng/mlvs.对照组177.7+/-71.7ng/ml)水平显著升高。两组间HA和COMP水平无显著差异。DLS的Cobb角与CPII呈显著正相关。这是首次对DLS的软骨生物标志物进行评估的研究。结果提示DLS患者有较高的II型胶原合成和降解水平，分别表现为血清CPII和C2C的升高。由于II型胶原是髓核和小关节软骨中胶原的主要成分，其转化能力的增强可能与DLS的发生发展有关。(C)2012年骨科研究会。由威利期刊出版公司出版，《矫形外科杂志》2012年版30：12491253
Several biomarkers have been used to evaluate osteoarthritis of the limb joints. Here we evaluated the use of serum cartilage metabolites as biomarkers for degenerative lumbar scoliosis (DLS). Fifty-two DLS patients with Cobb angle?>?10 degrees were compared with 19 control patients. Serum levels of hyaluronic acid (HA), keratan sulfate (KS), cartilage oligomeric matrix protein (COMP), collagen type II cleavage (C2C), and procollagen type II C-propeptide (CPII) were measured. Serum levels of KS (DLS 1.20 +/- 0.44 mu g/ml vs. control 0.98 +/- 0.33 mu g/ml), CPII (DLS 1905.1 +/- 948.2?ng/ml vs. control 1223.6 +/- 884.4?ng/ml), and C2C (DLS 219.1 +/- 59.2?ng/ml vs. control 177.7 +/- 71.7?ng/ml) were significantly higher in DLS. There were no significant differences in the levels of HA or COMP. There was a significant positive correlation between the Cobb angle and CPII in DLS. This is the first study to evaluate the cartilage biomarkers in DLS. The results suggest DLS patients have higher levels of type II collagen synthesis and degradation, indicated by elevated serum CPII and C2C, respectively. As type II collagen is a major component of collagens in the nucleus pulposus and facet joint cartilages, its enhanced turnover may be related to the development and progression of DLS. (C) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:12491253, 2012