Neurogenesis-dependent transformation of hippocampal engrams.
Neurogenesis-dependent transformation of hippocampal engrams.
复制标题
海马印迹的神经发生依赖性转化。
DOI：
10.1016/j.neulet.2021.136176
复制
发表时间：
2021
影响因子：
2.5
通讯作者：
Frankland,PaulW
中科院分区：
文献类型：
--
作者：
Ko,SangyoonY;Frankland,PaulW
在人类和其他哺乳动物中，对事件的记忆是由海马体中的神经元集合（或印记）编码的。储存在这些印迹中的助记信息可以用来指导未来的行为，包括在动态环境中的预测和决策。虽然一些海马体的印痕可能会被长期储存，但其他的会随着时间的推移而改变，这表明所代表的记忆也可能会被改变。随着时间的推移，海马体的印痕是如何改变的？成人海马神经发生代表了一个不断重新连接海马回路的过程，可能包括储存的海马印痕。在中间阶段，我们提出神经发生介导的海马印痕电路的重新布线导致特定刺激属性的遗忘，并且这种不太精确的印痕允许普遍化。在更高级的阶段，我们提出神经发生介导的海马印痕电路的重新布线导致海马印痕的沉默，使它们不再被自然检索线索所访问。
In humans and other mammals, memories of events are encoded by neuronal ensembles (or engrams) in the hippocampus. The mnemonic information stored in these engrams can then be used to guide future behavior, including prediction- and decision-making in dynamic environments. While some hippocampal engrams may be persistently stored, others are modified over time, suggesting that the represented memories may also be transformed. How might hippocampal engrams be modified through time? Adult hippocampal neurogenesis represents one process that continuously rewires hippocampal circuitry, presumably including stored hippocampal engrams. At intermediate stages, we propose that neurogenesis-mediated rewiring of hippocampal engram circuitry induces forgetting of specific stimulus attributes, and this less precise engram allows for generalization. At more advanced stages, we propose that neurogenesis-mediated rewiring of hippocampal engram circuitry leads to silencing of hippocampal engrams, rendering them no longer accessible by natural retrieval cues.