The innate immune signaling in cancer and cardiometabolic diseases: Friends or foes?
The innate immune signaling in cancer and cardiometabolic diseases: Friends or foes?
复制标题
癌症和心脏代谢疾病中的先天免疫信号：是朋友还是敌人？
DOI：
10.1016/j.canlet.2016.06.004
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发表时间：
2017
期刊：
影响因子：
9.7
通讯作者：
Li Hongliang
中科院分区：
文献类型：
--
作者：
Wang Weijun;Zhang Yaxing;Yang Ling;Li Hongliang
先天免疫系统负责通过几种类型的生殖线编码的模式识别受体(PRR)来感知病原体相关分子模式(PAMP)或危险相关分子模式(DAMP)。它有能力帮助人体在正常情况下保持动态平衡。然而，在病理条件下，PAMP或DAMP会触发异常的先天免疫和炎症反应，从而对癌症和心脏代谢性疾病的进展产生负面或积极的影响。有趣的是，我们发现先天免疫信号的某些成分部分地以非免疫依赖的方式参与了这些疾病，这表明对先天免疫信号在这些疾病中的作用有更深入的了解。本文就天然免疫信号转导途径及其与癌症和心脏代谢性疾病的关系作一综述，以期为这些疾病的治疗提供有效的方法。
The innate immune system is responsible for sensing pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) by several types of germline-encoded pattern-recognition receptors (PRRs). It has the capacity to help the human body maintain homeostasis under normal conditions. However, in pathological conditions, PAMPs or DAMPs trigger aberrant innate immune and inflammatory responses and thus negatively or positively influence the progression of cancer and cardiometabolic diseases. Interestingly, we found that some elements of innate immune signaling are involved in these diseases partiallyviaimmune-independent manners, indicating a deeper understanding of the function of innate immune signaling in these diseases is urgent. In this review, we summarize the primary innate immune signaling pathways and their association with cancer and cardiometabolic diseases, with the aim of providing effective therapies for these diseases.