Placental passage of antidepressant medications
Placental passage of antidepressant medications
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DOI：
10.1176/appi.ajp.160.5.993
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发表时间：
2003-05-01
影响因子：
17.7
通讯作者：
Haynes, D
中科院分区：
文献类型：
--
作者：
Hendrick, V;Stowe, ZN;Haynes, D
目的：本研究测定了抗抑郁药及其代谢产物的胎盘转运。方法：共38名孕妇服用西酞普兰，氟西汀，帕罗西汀，舍曲林参加。结果：86.8%的新生儿脐带血中抗抑郁药及其代谢物浓度可检出。脐带与母体血清浓度的平均比值范围为0.29至0.89。舍曲林和帕罗西汀的比例最低，西酞普兰和氟西汀的比例最高。舍曲林和氟西汀的母亲剂量与脐带浓度这些medications.Conclusions：脐带浓度的抗抑郁药及其代谢产物几乎总是低于相应的母亲浓度。母体剂量预测氟西汀和舍曲林的脐浓度。舍曲林组的平均脐带与母体血清比值显著低于氟西汀组，表明舍曲林在分娩前产生的胎儿药物暴露量可能低于氟西汀。
Objective: This study determined the placental transfer of antidepressants and their metabolites.Method: A total of 38 pregnant women taking citalopram, fluoxetine, paroxetine, or sertraline participated. Maternal and umbilical cord blood samples were obtained to determine antidepressant and metabolite concentrations.Results: Antidepressant and metabolite concentrations were detectable in 86.8% of umbilical cord samples. The mean ratios of umbilical cord to maternal serum concentrations ranged from 0.29 to 0.89. The lowest ratios were for sertraline and paroxetine; the highest were for citalopram and fluoxetine. Maternal doses of sertraline and fluoxetine correlated with umbilical cord concentrations of these medications.Conclusions: Umbilical cord concentrations of antidepressants and their metabolites were almost invariably lower than corresponding maternal concentrations. Maternal doses predicted umbilical concentrations of fluoxetine and sertraline. Mean umbilical cord to maternal serum ratios were significantly lower for sertraline than fluoxetine, suggesting that sertraline may produce less fetal medication exposure than fluoxetine near delivery.