Is Gulf War Illness a prolonged early phase tauopathy?
Is Gulf War Illness a prolonged early phase tauopathy?
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DOI：
10.1002/cm.21786
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发表时间：
2023-09-13
期刊：
影响因子：
2.9
通讯作者：
Qiang，Liang
中科院分区：
文献类型：
--
作者：
Baas，Peter W.;Sullivan，Kimberly A.;Qiang，Liang
近年来，海湾战争疾病（GWI）联盟以及美国各地的基础和临床研究人员的工作使人们更好地了解了GWI的病理基础以及这种疾病的潜在机制。患有GWI的退伍军人所遭受的最令人担忧的症状之一是认知减退，包括与记忆功能有关的症状。这些减少还不足以达到痴呆症的标准，但人们非常担心这些退伍军人的轻度认知障碍会随着年龄的增长而发展为痴呆症。最近使用人脑类器官和大鼠模型对GWI进行的研究表明，认知问题的一个潜在原因可能是大脑中tau水平升高，这得到了退伍军人血液中高水平tau自身抗体的支持。迫切需要在这些退伍军人进展为痴呆症之前为他们找到治疗和预防策略，这样做具有附加价值，因为他们目前的状态可能代表许多神经退行性疾病常见的tau蛋白病的早期阶段。
The work of the Gulf War Illness (GWI) Consortium and that of basic and clinical researchers across the USA have resulted in a better understanding in recent years of the pathological basis of GWI, as well as of the mechanisms underlying the disorder. Among the most concerning symptoms suffered by veterans with GWI are cognitive decrements including those related to memory functioning. These decrements are not severe enough to meet dementia criteria, but there is significant concern that the mild cognitive impairment of these veterans will progress to dementia as they become older. Recent studies on GWI using human brain organoids as well as a rat model suggest that one potential cause of the cognitive problems may be elevated levels of tau in the brain, and this is supported by high levels of tau autoantibodies in the blood of veterans with GWI. There is urgency in finding treatments and preventive strategies for these veterans before they progress to dementia, with added value in doing so because their current status may represent an early phase of tauopathy common to many neurodegenerative diseases.