Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study
Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study
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DOI：
10.1016/j.joca.2010.10.014
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发表时间：
2011-01-01
影响因子：
7
通讯作者：
Doherty, M.
中科院分区：
文献类型：
--
作者：
Holliday, K. L.;McWilliams, D. F.;Doherty, M.
目的：研究成年早期超重人群患大关节骨关节炎(OA)的风险，并评估高体重指数(BMI)和其他肥胖人体测量指标的风险。方法：在目标病例对照研究中测量BMI、腰围和臀围，包括髋关节骨关节炎(n=1007)、膝关节骨关节炎(n=1042)和无症状对照(n=1121)。对终生体重、体型和其他危险因素的回溯性估计是通过访谈-领导问卷收集的。结果：BMI与膝关节骨性关节炎相关(AOR 2.68，95%CI 2.33~3.09，P趋势
Objective: To examine the risk of large joint osteoarthritis (OA) in those becoming overweight during early adult life, and to assess the risks associated with high body mass index (BMI) and other anthropometric measures of obesity.Methods: BMI, waist and hip circumference were measured in the GOAL case-control study comprising hip OA cases (n = 1007), knee OA cases (n = 1042) and asymptomatic controls (n = 1121). Retrospective estimates of lifetime weight, body shape and other risk factors were collected using an interview-lead questionnaire. Odds ratios (ORs), adjusted OR (aOR), 95% confidence intervals (Os) and P values were calculated using logistic regression analysis.Results: BMI was associated with knee OA (aOR 2.68, 95% CI 2.33-3.09, P-trend