Hierarchical Self-Assembly of Responsive Organoplatinum(II) Metallacycle-TMV Complexes with Turn-On Fluorescence
Hierarchical Self-Assembly of Responsive Organoplatinum(II) Metallacycle-TMV Complexes with Turn-On Fluorescence
复制标题
具有开启荧光的响应性有机铂 (II) 金属环-TMV 配合物的分级自组装
DOI：
10.1021/jacs.6b07402
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发表时间：
2016-09-21
影响因子：
15
通讯作者：
Stang, Peter J.
中科院分区：
文献类型：
--
作者：
Tian, Ye;Yan, Xuzhou;Stang, Peter J.
在这里，我们报道了具有带负电荷的表面的棒状烟草花叶病毒（TMV）可以通过与带正电荷的分子“胶水”（即基于四苯乙烯（TPE）的离散有机铂（II）金属环（TPE-Pt-MC））的多重静电相互作用组装成三维微米大小的束状上层结构。由于所得TMV/TPE-Pt-MC复合物中的纳米限制效应和TPE单元的聚集诱导发射（ATE）活性，这些分层结构导致显着的荧光增强，这不仅为新型金属有机生物杂化材料的形成提供了证据，而且代表了开启荧光的替代方案。此外，这些最终构建体的解离和随后单个病毒的释放是通过使用四丁基溴化铵 (TBAB) 破坏 TPE-Pt-MC 核心来实现的。该策略还与其他基于蛋白质的纳米粒子（例如噬菌体 M13 和铁蛋白）兼容，证明了该方法的通用性。因此，这项研究将为涉及金属有机配合物和各向异性形状的生物纳米颗粒的功能性生物杂化材料的制造开辟新途径。
Here we report that the rod-like tobacco mosaic virus (TMV), having a negatively charged surface, can be assembled into three-climensional micrometer-sized bundle-like superstructures via multiple electrostatic interactions with a positively charged molecular "glue", namely, a tetraphenylethylene (TPE)-based discrete organoplatinum(II) metallacycle (TPE-Pt-MC). Due to the nanoconfinement effect in the resultant TMV/TPE-Pt-MC complexes and the aggregation-induced emission (ATE) activity of the TPE units, these hierarchical architectures result in a dramatic fluorescence enhancement that not only provides evidence for the formation of novel metal organic biohybrid materials but also represents an alternative to turn-on fluorescence. Moreover, the dissociation of these final constructs and subsequent release of individual virus have been achieved by disrupting the TPE-Pt-MC core using tetrabutylammonium bromide (TBAB). This strategy is also compatible with other protein-based nanoparticles such as bacteriophage M13 and ferritin, proving the generality of this approach. Hence, this research will open new routes for the fabrication of functional biohybrid materials involving metal organic complexes and anisotropically shaped bionanoparticles.