Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging.
Acute hyperglycemia compromises cerebral blood flow following cortical spreading depression in rats monitored by laser speckle imaging.
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DOI：
10.1117/1.3041710
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发表时间：
2008-11
影响因子：
3.5
通讯作者：
Zhen Wang;W. Luo;Pengcheng Li;Jianjun Qiu;Qingming Luo
中科院分区：
文献类型：
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作者：
Zhen Wang;W. Luo;Pengcheng Li;Jianjun Qiu;Qingming Luo
高血糖和皮质扩散性抑制（CSD）可能是导致缺血性脑卒中预后恶化的因素，高血糖和CSD对脑血流（CBF）的影响可能存在长期协同作用。在大鼠急性高血糖期间，对CSD后CBF变化的长期和全场观察可能会显示情况是否如此。在这里，我们利用激光散斑成像研究了急性高血糖对正常大鼠和CSD大鼠单个血管室水平CBF的影响，持续3 h。结果表明，急性高血糖时大鼠大脑皮质小动脉和脑实质的CBF较正常大鼠皮层广泛增加，而小静脉的CBF无明显变化。我们还发现，在所有的血管室，在葡萄糖给药后，CSD后CBF逐步减少，但在盐水注射后，CSD后CBF接近基线。我们的研究结果表明，急性高血糖可加重CSD后CBF下降的严重程度，提示高血糖加重缺血性卒中后脑损伤的可能机制。
Hyperglycemia and cortical spreading depression (CSD) are possible factors that worsen the outcome of ischemic stroke, and it is probable that there is a longterm cooperative effect of hyperglycemia and CSD on cerebral blood flow (CBF). Long-lasting and full-field observation of changes in CBF following CSD in vivo during acute hyperglycemia in rats might show whether this is the case. Here, we utilized laser speckle imaging to study influences of acute hyperglycemia on CBF at the level of individual vascular compartments for 3 h in normal rats and those with CSD. It is shown that there are extensive increases of CBF at the arteriole and parenchyma over the normal rat cortex during acute hyperglycemia, whereas there is no significant change in CBF at the venule. We also find that, at all vascular compartments, after the glucose administration there is a stepwise reduction of CBF following CSD, but after saline injection CBF following CSD is close to the baseline. Our results indicate that acute hyperglycemia could aggravate the severity of decrease in CBF following CSD, suggesting possible mechanisms by which hyperglycemia exacerbates cerebral damage after ischemic stroke.