Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.
Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.
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理智与情感：ATM 氧应激信号控制脑细胞能量。
DOI：
10.1083/jcb.201901050
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Schlacher,Katharina
中科院分区：
文献类型：
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作者：
Schlacher,Katharina
共济失调-毛细血管扩张突变（ATM）基因调节DNA损伤修复，氧化应激和线粒体过程。在这个问题上，Chow et al.（2019. J. Cell Biol. https：//doi.org/10.1083/jcb.201806197）将ATM的氧化应激反应功能与代谢ATP能量学的传感联系起来，这在高能量需求的浦肯野脑细胞中特别重要，这可以解释最明显的A-T患者特征，小脑共济失调。
The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM’s oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy–demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia.