Avian influenza in birds and mammals
Avian influenza in birds and mammals
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DOI：
10.1016/j.cimid.2008.01.001
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发表时间：
2009-07-01
影响因子：
2
通讯作者：
Davis, Cristina E.
中科院分区：
文献类型：
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作者：
Cardona, Carol J.;Xing, Zheng;Davis, Cristina E.
由禽流感病毒引起的疾病综合征是高度可变的，这取决于感染的宿主物种、其对感染的易感性和反应以及感染病毒株的毒力。虽然禽流感病毒一般具有广泛的宿主范围，但单个毒株或亚型感染一个以上物种的情况很少。H5 N1型高致病性禽流感病毒（HPAIV）是由A/goose/Guandong/96（H5 N1 HPAIV）病毒衍生而来的一种病毒，其在世界范围内感染的物种多样性是不寻常的。虽然在野外和实验研究中受H5 N1高致病性禽流感影响的物种是多样的，但它们相关的疾病症状在物种之间非常相似。在某些物种中，多器官衰竭和死亡是迅速的，没有观察到疾病的迹象。这一类别中最突出的是鸡和鸡形目的其他鸟类。在其他物种中，神经系统症状的发展导致宿主死亡。这是在家猫（食肉目）、鹅（雁形目）、平胸类（鸵鸟形目）、高剂量接种的鸽子（鸽形目）和自2002年以来感染H5 N1 HPAIV的鸭（雁形目）中报告的情况。在其他一些物种中，疾病更持久，尽管多器官衰竭和死亡是最终结果，但疾病的迹象更广泛。这些物种主要包括人类（灵长类）和人类疾病的实验室模型，雪貂（食肉目），小鼠（啮齿目）和猕猴（灵长类）。最后，一些物种对H5 N1感染的抵抗力更强
The disease syndromes caused by avian influenza viruses are highly variable depending oil the host species infected, its susceptibility and response to infection and the virulence of the infecting viral strain. Although avian influenza viruses have it broad host range in general, it is rare for an individual strain or subtype to infect more than one species. The H5N1 highly pathogenic avian influenza virus (HPAIV) lineages of viruses that descended from A/goose/Guandong/96 (H5N1 HPAIV) are unusual in the diversity of species they have infected worldwide. Although the species affected by H5N1 HPAI in the field and those that have been experimentally studied are diverse, their associated disease syndromes are remarkably similar across species. In some species, multi-organ failure and death are rapid and no signs of the disease are observed. Most prominently in this category are chickens and other avian species of the order Galliformes. In other species, neurologic signs develop resulting in the death of the host. This is what has been reported in domestic cats (Carnivora), geese (Anseriformes), ratites (Struthioniformes), pigeons inoculated with high doses (Columbiformes) and ducks infected with H5N1 HPAIV isolated since 2002 (Anseriformes). In some other species, the disease is more prolonged and although multi-organ failure and death are the eventual outcomes, the signs of disease are more extensive. Predominantly, these species include humans (Primates) and the laboratory models of human disease, the ferret (Carnivora), mouse (Rodentia) and cynamologous macaques (Primates). Finally, some species are more resistant to infection with H5N1