Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: Postal and telephone survey of travellers
Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: Postal and telephone survey of travellers
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DOI：
10.1136/bmj.313.7056.525
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发表时间：
1996-08-31
影响因子：
--
通讯作者：
Bradley, DJ
中科院分区：
文献类型：
--
作者：
Barrett, PJ;Emmins, PD;Bradley, DJ
比较甲氟喹和氯喹加氯胍用于疟疾化学预防的不良事件，特别是神经精神影响的频率。设计回顾性调查问卷，对1993年11月至1995年2月期间服用任一方案的旅行者进行调查;对那些报告有明显副作用的人进行电话采访。背景--来自英国的旅行者咨询了一个咨询热线。主题--1214成年人服用甲氟喹和1181服用氯喹加proguanil.Main结果测量报告的存在和残疾程度从12神经精神和其他症状，评估的主题和裁判和行为的基础上changes.Results-There是平等的任何副作用（40%）和停止或改变药物治疗。总体而言，神经精神不良事件在服用甲氟喹的旅行者中明显更常见。1214名服用甲氟喹的旅行者共报告了333起神经精神不良事件，而1181名服用氯胍加氯喹的旅行者共报告了189起神经精神不良事件（P
Objective-To compare the frequency of adverse events, particularly neuropsychiatric effects, from mefloquine and from chloroquine plus proguanil as used for malaria chemoprophylaxis.Design-Retrospective questionnaire to travellers taking either regimen between November 1993 and February 1995; telephone interview with those reporting pronounced side effects.Setting-Travellers from Britain who consulted an advisory helpline.Subjects-1214 adults taking mefloquine and 1181 taking chloroquine plus proguanil.Main outcome Measures-Reported presence of and degree of disability from 12 neuropsychiatric and other symptoms, as assessed by the subjects and by referees and on the basis of behaviour change.Results-There were equal rates of any side effects (40%) and of stopping or changing medication. Overall, neuropsychiatric adverse events were significantly more common in travellers taking mefloquine. In all, 333 neuropsychiatric adverse events were reported by 1214 travellers taking mefloquine, compared with 189 such events in 1181 travellers taking proguanil plus chloroquine (P