REDUCING THE RISK OF AIDS THROUGH METHADONE-MAINTENANCE TREATMENT
REDUCING THE RISK OF AIDS THROUGH METHADONE-MAINTENANCE TREATMENT
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DOI：
10.2307/2137033
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发表时间：
1988-09-01
影响因子：
5
通讯作者：
FRIEDMAN, SR
中科院分区：
文献类型：
--
作者：
BALL, JC;LANGE, WR;FRIEDMAN, SR
在纽约市（美国）的一个为期三年的美沙酮维持方案领域中，费城和巴尔的摩的研究发现，治疗在减少大多数海洛因成瘾者的静脉注射毒品和共用针头方面是有效的。在388名持续治疗一年或一年以上的患者中，71%的患者停止了静脉注射。相反，82%离开治疗的患者迅速复发到IV药物使用。观察到各种方案的有效性存在显著差异：在特定治疗方案中，目前静脉注射的使用率从不到10%到超过57%不等。这种不同的有效性与患者的住院时间和提供的治疗质量有关。高危吸毒者中艾滋病毒血清反应阳性与注射和共用针头接触的频率有关。有效的美沙酮治疗可以阻止这些做法，但对艾滋病流行的广泛影响将需要在许多项目中改善治疗。
In a three-year field of methadone maintenance programs in New York City (U.S.A.) Philadelphia, and Baltimore, treatment was found to be effective in reducing Iv drug use and needle sharing among most heroin addicts. Of 388 patients who remained in treatment for one year or more, 71 percent had ceased IV use. Conversely, 82 percent of patients who left treatment relapsed rapidly to IV drug use. Marked differences in the effectiveness of various programs were observed: current Iv use varied from less than 10 percent to over 57 percent of patients in particular treatment programs. This differential effectiveness was related both to length of patient''s stay and the quality of treatment provided. HIV seropositivity among high-risk drug users is related to frequency of injections and needle-sharing contacts. Effective methadone treatment can stop these practices, but a widespread impact on the AIDS epidemic will require improvement of treatment in many programs.