Ventral attention and motor network connectivity is relevant to functional impairment in spatial neglect after right brain stroke
Ventral attention and motor network connectivity is relevant to functional impairment in spatial neglect after right brain stroke
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DOI：
10.1016/j.bandc.2018.11.013
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发表时间：
2019-02-01
影响因子：
2.5
通讯作者：
Saleh, Soha
中科院分区：
文献类型：
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作者：
Barrett, A. M.;Boukrina, Olga;Saleh, Soha
新的研究表明，右中风后的空间忽视与注意力和运动网络功能障碍有关。先进的功能连通性分析阐明了大脑网络的恢复，但我们需要知道网络如何参与适应性运动表现。我们需要验证在空间忽视中与有效的功能测量和空间运动表现相关的网络变化，特别是在有大的脑损伤和显著残疾的患者中。本研究检验了与残疾相关的空间忽略是否与运动注意网络、背侧注意网络和腹侧注意网络(MN、DAN和VAN)之间不同的静息状态功能连接模式有关。在常规行为注意力测试中，右侧卒中患者存在空间忽视(n=8)或无空间忽略(n=10)。空间忽略患者的VAN内部网络连接性较弱，VAN与左额叶视野(DAN)、VAN与左侧主要运动区(MN)之间的网络连接性降低。这些网络损伤可能解释了空间忽视中注意缺陷和运动缺陷并存的原因，并为在中风后空间再训练和运动康复的联合临床试验中评估功能连通性开辟了一条道路。
Emerging research suggests spatial neglect after right stroke is linked to dysfunctional attention and motor networks. Advanced functional connectivity analysis clarified brain network recovery, however we need to know how networks participate in adaptive motor performance. We need to verify network changes associated with validated functional measures and spatial-motor performance in spatial neglect, especially in patients with large brain lesions and significant disability. This study tested whether disability-relevant spatial neglect associates with different patterns of resting state functional connectivity between motor, dorsal and ventral attention networks (MN, DAN and VAN). Right stroke patients had spatial neglect (n = 8) or not (n = 10) on the Behavioural Inattention Test-conventional. Spatial neglect patients had weaker intranetwork VAN connectivity, and reduced internetwork connectivity between VAN and left frontal eye field (DAN), and between VAN and the left primary motor area (MN). These network impairments might explain the co-occurrence of attention and motor deficits in spatial neglect, and open a path to assessing functional connectivity in clinical trials of combined spatial retraining and motor rehabilitation after stroke.