Biomolecular events in cancer revealed by attractor metagenes.
Biomolecular events in cancer revealed by attractor metagenes.
复制标题
DOI：
10.1371/journal.pcbi.1002920
复制
发表时间：
2013
影响因子：
4.3
通讯作者：
Anastassiou D
中科院分区：
文献类型：
--
作者：
Cheng WY;Ou Yang TH;Anastassiou D
Mining gene expression profiles has proven valuable for identifying signatures serving as surrogates of cancer phenotypes. However, the similarities of such signatures across different cancer types have not been strong enough to conclude that they represent a universal biological mechanism shared among multiple cancer types. Here we present a computational method for generating signatures using an iterative process that converges to one of several precise attractors defining signatures representing biomolecular events, such as cell transdifferentiation or the presence of an amplicon. By analyzing rich gene expression datasets from different cancer types, we identified several such biomolecular events, some of which are universally present in all tested cancer types in nearly identical form. Although the method is unsupervised, we show that it often leads to attractors with strong phenotypic associations. We present several such multi-cancer attractors, focusing on three that are prominent and sharply defined in all cases: a mesenchymal transition attractor strongly associated with tumor stage, a mitotic chromosomal instability attractor strongly associated with tumor grade, and a lymphocyte-specific attractor. Cancer is known to be characterized by several unifying biological capabilities or “hallmarks.” However, attempts to computationally identify patterns, such as gene expression signatures, shared across many different cancer types have been largely unsuccessful. A typical approach has been to classify samples into mutually exclusive subtypes, each of which is characterized by a particular gene signature. Although occasional similarities of such signatures in different cancer types exist, these similarities have not been sufficiently strong to conclude that they reflect the same biological event. By contrast, we have developed a computational methodology that has identified some signatures of co-expressed genes exhibiting remarkable similarity across many different cancer types. These signatures appear as stable “attractors” of an iterative computational procedure that tends to collect mutually associated genes, so that its convergence can point to the core (“heart”) of the underlying biological co-expression mechanism. One of these “pan-cancer” attractors corresponds to a transdifferentiation of cancer cells empowering them with invasiveness and motility. Another represents a mitotic chromosomal instability of cancer cells. A third attractor is lymphocyte-specific.
登录
查看更多内容
影响因子：
37.3
作者：
Amato A;Schillaci T;Lentini L;Di Leonardo A
通讯作者：
Di Leonardo A
影响因子：
11.2
作者：
Birkbak NJ;Eklund AC;Li Q;McClelland SE;Endesfelder D;Tan P;Tan IB;Richardson AL;Szallasi Z;Swanton C
通讯作者：
Swanton C
影响因子：
11.2
作者：
Matsushita, K;Tomonaga, T;Ochiai, T
通讯作者：
Ochiai, T
影响因子：
64.5
作者：
Dai, Chengkai;Whitesell, Luke;Lindquist, Susan
通讯作者：
Lindquist, Susan
影响因子：
8
作者：
Lee, Y. J.;Lee, H. J.;Lee, Y. S.
通讯作者：
Lee, Y. S.