Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health.
Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health.
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DOI：
10.1186/s12866-017-1012-8
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发表时间：
2017-04-27
期刊：
影响因子：
4.2
通讯作者：
Zarrilli R
中科院分区：
文献类型：
--
作者：
Khan AU;Maryam L;Zarrilli R
产碳青霉烯酶细菌尤其是新德里产金属β-内酰胺酶（NDM-1）及其变异株在世界范围内的出现引起了重大的公共卫生问题。NDM-1水解广泛的β-内酰胺类抗生素，包括碳青霉烯类，碳青霉烯类是治疗由耐药菌株引起的感染的抗生素的最后手段。在这篇综述中，我们讨论了bla NDM-1变体、其遗传分析，包括特定突变类型、国家起源以及在几种细菌物种中的传播。肠杆菌科的广泛成员，最常见的是大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌和革兰氏阴性非发酵菌假单胞菌属。和鲍曼不动杆菌携带这些标记。此外，迄今为止，在来自不同国家的不同种类的细菌中，已经报道了至少十七种bla NDM型基因的变体，其在不同位置上的氨基酸的一个或两个残基不同。这些变异体的遗传和结构研究对于理解抗生素水解的机制以及设计对抗生素具有抑制活性的新分子是重要的。本文综述了NDM-1变异体之间的结构差异，这是它们在地球仪传播背后的驱动力。本文的在线版本（doi：10.1186/s12866-017-1012-8）包含补充材料，可供授权用户使用。
The emergence of carbapenemase producing bacteria, especially New Delhi metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health concern. NDM-1 hydrolyzes a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria. In this review, we have discussed bla NDM-1variants, its genetic analysis including type of specific mutation, origin of country and spread among several type of bacterial species. Wide members of enterobacteriaceae, most commonly Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and gram-negative non-fermenters Pseudomonas spp. and Acinetobacter baumannii were found to carry these markers. Moreover, at least seventeen variants of bla NDM-type gene differing into one or two residues of amino acids at distinct positions have been reported so far among different species of bacteria from different countries. The genetic and structural studies of these variants are important to understand the mechanism of antibiotic hydrolysis as well as to design new molecules with inhibitory activity against antibiotics. This review provides a comprehensive view of structural differences among NDM-1 variants, which are a driving force behind their spread across the globe. The online version of this article (doi:10.1186/s12866-017-1012-8) contains supplementary material, which is available to authorized users.