Bisphenol A and Chronic Disease Risk Factors in US Children
Bisphenol A and Chronic Disease Risk Factors in US Children
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DOI：
10.1542/peds.2013-0106
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发表时间：
2013-09-01
期刊：
影响因子：
8
通讯作者：
Padmanabhan, Vasantha
中科院分区：
文献类型：
--
作者：
Eng, Donna S.;Lee, Joyce M.;Padmanabhan, Vasantha
目的：评估尿双酚A(BPA)水平与肥胖测量和慢性病危险因素的关系。方法：我们使用NHANES 2003-2010来评估6至18岁儿童的尿双酚A(BPA)水平与肥胖、胆固醇、胰岛素和血糖的多项测量之间的横断面关联，调整相关协变量(例如，人口统计学、尿肌酐、烟草暴露和汽水摄入量)。结果：我们发现肥胖的几率(BMI和GT；=95百分位数)，四分位数2对1(优势比[OR]1.74，95%可信区间[CI]1.17-2.60，P=0.008)，3对1(优势比1.64，95%可信区间1.09-2.47，P=0.02)，4对1(优势比2.01，95%可信区间1.36-2.98，P=.001)。我们还发现腰围身高比异常的几率更高(四分位数2比1[OR1.37，95%CI 0.98-1.93，P=0.07]，3vs1[OR1.41，95%CI1.07-1.87，P=0.02]，4vs1[OR1.55，95%CI1.12-2.15，P=0.01])。我们没有发现BPA与任何其他慢性疾病风险因素之间的显著关联。结论：尿中BPA水平越高，肥胖(BMI>；95%)和腰围/身高比异常的几率越高。需要进行纵向分析来阐明双酚A暴露与儿童肥胖和慢性病危险因素发展之间的时间关系。
OBJECTIVE: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample.METHODS: We used the NHANES 2003-2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption).RESULTS: We found a higher odds of obesity (BMI >= 95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). We also found a higher odds of having an abnormal waist circumference-to-height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98-1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07-1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12-2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.CONCLUSIONS: Higher levels of urinary BPA were associated with a higher odds of obesity (BMI >95%) and abnormal waist circumference-to-height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children.