Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.
Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.
复制标题
芬兰扩展谱系中 Xq24-q27.1 上双相情感障碍易感位点的证据。
作者：
P. Pekkarinen;J. Terwilliger;P. Bredbacka;J. Lönnqvist;L. Peltonen
自1969年以来，在一些具有表型标记的家系中，如色盲、葡萄糖-6-磷酸脱氢酶缺乏症和凝血因子IX缺乏症，X染色体易感基因被认为是躁郁症的易感基因。然而，确凿的证据和推测的X染色体基因座的确切位置仍然存在争议。我们在这里报告了凝血因子IX基因附近的DNA标记与双相情感障碍之间的联系，该基因来自芬兰遗传隔离的人群的扩展家系。Xq24-q27.1上覆盖20-cM区域的独特的染色体单倍型可被证明分离为双相情感障碍。这些发现应该会鼓励研究小组研究具有Xq24-q27.1标记的大家族材料，最终解决双相情感障碍的X染色体连锁问题。
An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.
躁狂抑郁（双相 I）疾病的家庭研究。
影响因子：
--
作者：
Winokur,G;Coryell,W;Keller,M;Endicott,J;Leon,A
通讯作者：
Leon,A