Histone Deacetylases 1 and 2 in Memory Function.
Histone Deacetylases 1 and 2 in Memory Function.
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DOI：
10.1021/acschemneuro.1c00775
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发表时间：
2022-03
影响因子：
5
通讯作者：
P. Pao;L. Tsai
中科院分区：
文献类型：
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作者：
P. Pao;L. Tsai
组蛋白脱乙酰酶(HDAC)与学习和记忆有关，它们的失调与脑老化和神经退行性疾病的认知障碍有关。在这篇综述中，我们重点介绍了HDAC1和HDAC2，强调了它们通过不同的机制调节大脑功能的最新进展，包括基因抑制和DNA修复途径。此外，我们还讨论了HDAC1和HDAC2如何被调节的证据，以及它们作为对抗记忆缺陷的靶点的潜力。
Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits.