Advance in microRNA as a potential biomarker for early detection of pancreatic cancer.
Advance in microRNA as a potential biomarker for early detection of pancreatic cancer.
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DOI：
10.1186/s40364-016-0074-3
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发表时间：
2016
影响因子：
11.1
通讯作者：
Xiao GG
中科院分区：
文献类型：
--
作者：
Huang J;Liu J;Chen-Xiao K;Zhang X;Lee WN;Go VL;Xiao GG
由于临床上缺乏有效的诊断和治疗策略，胰腺癌是一种生存率低、死亡率高的疾病。常规的临床诊断方法包括血清标志物和影像学检查（CT、MRI、EUS等）往往不能发现癌前病变或早期病变。开发有效的生物标志物来降低胰腺癌的死亡率是不现实的。MicroRNAs （miRNAs）是一组小的非蛋白质编码rna，在肿瘤发生、凋亡逃逸、增殖、侵袭、上皮-间质转化（EMT）、转移和化疗耐药等细胞生理调控中发挥重要作用。参与胰腺癌分子发病的多种信号通路的改变是由microrna作为癌基因或肿瘤抑制因子介导的。在已开发的蛋白质、代谢物、DNA、RNA、表观遗传突变等生物标志物中，miRNAs因其独特的化学性质而具有优势。最近的研究表明，mirna可能是用于胰腺癌早期检测的有希望的生物标志物。这篇综述将更新胰腺癌早期检测的进展。
Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods including serum markers and radiological imaging (CT, MRI, EUS, etc.) often fail to detect precancerous or early stage lesions. Development of effective biomarkers is unmet for reduction of mortality of pancreatic cancer. MicroRNAs (miRNAs) are a group of small non-protein-coding RNAs playing roles in regulation of cell physiology including tumorigenesis, apoptotic escape, proliferation, invasion, epithelial-mesenchymal transition (EMT), metastasis and chemoresistance. Various altered signaling pathways involving in molecular pathogenesis of pancreatic cancer are mediated by miRNAs as a role of either oncogenes or tumor suppressors. Among biomarkers developed including protein, metabolites, DNA, RNA, epigenetic mutation, miRNAs are superior because of its unique chemical property. Recent study suggests that miRNAs may be promising biomarkers used for early detection of pancreatic cancer. This review will update the progression made in early detection of pancreatic cancer.