Parkinson's disease and reproductive life events
Parkinson's disease and reproductive life events
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DOI：
10.1007/s100720200082
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发表时间：
2002-09-01
影响因子：
3.3
通讯作者：
Nappi, G
中科院分区：
文献类型：
--
作者：
Martignoni, E;Nappi, RE;Nappi, G
帕金森氏病(PD)的发病、进展和病程似乎在男性和女性中相似，但在临床方面存在性别差异，如男性更严重的疾病和女性更多的运动障碍。考虑到性激素，特别是雌激素对基底节功能的多重影响，本研究比较了帕金森病患者和健康女性的生殖事件的特征，包括疾病的发病和临床方面的生殖生活里程碑。共有150名帕金森病妇女和200名年龄匹配的健康妇女接受了关于生殖生活和疾病特征(如果患者)的采访。作为一个整体，帕金森病患者的月经初潮时间晚于对照组，但在正常范围内。更年期在时间、类型(自然)和开始(缓慢)方面与对照组相似，但激素治疗较少。患有帕金森病的妇女生育的孩子较少，而母乳喂养和妇科疾病与对照组相当。月经特征与痛经和经前综合征相似。绝经前发病的帕金森病患者病程更长，波动阶段更频繁，左旋多巴和多巴胺激动剂的治疗时间更长。与绝经后帕金森病患者和对照组相比，她们有更多的痛经和经前综合症。
Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and more dyskinesia in women. Taking into account the multiple influences of sex hormones, estrogens in particular, on basal ganglia function, the present work compared the characteristics of reproductive events in PD subjects and in healthy women, with regard to onset and clinical aspects of the disease with respect to the milestones of reproductive life. A total of 150 PD women and 200 healthy women matched for age were interviewed about reproductive life and disease characteristics (if patients). As a group, the women with PD had menarche later than the controls, but in the normal range. Menopause was similar to the controls for time, type (natural) and onset (slow), but with less hormonal therapies. Women with PD had fewer children, while breast feeding and gynecological diseases were comparable to controls. The characteristics of menses were similar as far as dysmenorrhea and premenstrual syndrome (PMS). The women with PD onset before menopause had a longer disease duration, with a more frequent fluctuating stage, and longer treatment with both levodopa and dopamine agonists. They had more dysmenorrhea and PMS when compared with women with PD onset after menopause and controls.