Malabsorption in Plasmodium falciparum malaria.
Malabsorption in Plasmodium falciparum malaria.
复制标题
恶性疟原虫疟疾的吸收不良。
DOI：
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发表时间：
1972
影响因子：
3.3
通讯作者：
M. Tong
中科院分区：
文献类型：
--
作者：
W. Karney;M. Tong
摘要
在恶性疟原虫疟疾患者的急性期发现胃肠道功能受损。9/11例（82%）D-木糖吸收减少，6/10例（60%）维生素B12吸收减少，5/11例（45%）血清胡萝卜素水平低。在恢复期，大多数吸收功能测试恢复正常。7例疟疾患者中6例空肠活检显示固有层水肿和圆形细胞浸润，绒毛缩短和增宽。在5例活检中，在粘膜血管内观察到疟疾色素和寄生红细胞的存在。在每种情况下，形态学变化恢复正常恢复期。疟疾吸收不良综合征的病理生理机制尚未阐明，但可能部分是由于小肠粘膜的缺血性变化。
Abstract
Impaired gastrointestinal function was detected during the acute phase of illness in patients with Plasmodium falciparum malaria. Nine of 11 (82%) had diminished D-xylose absorption, 6 of 10 (60%) had decreased absorption of vitamin B12, and 5 of 11 (45%) had low serum carotene levels. A majority of the tests for absorptive function returned toward normal during the convalescent period. Jejunal biopsies in 6 of 7 patients with malaria revealed edema and round cell infiltration of the lamina propria, and shortening and widening of villi. In 5 of these biopsies the presence of malarial pigment and parasitized red blood cells was noted within the mucosal vessels. In each case, the morphologic changes reverted toward normal during convalescence. The pathophysiologic mechanism responsible for the malabsorption syndrome in malaria has not been elucidated but may be due in part to ischemic changes in the mucosa of the small bowel.