LOSS OF LOCAL-CONTROL WITH PROLONGATION IN RADIOTHERAPY
LOSS OF LOCAL-CONTROL WITH PROLONGATION IN RADIOTHERAPY
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DOI：
10.1016/0360-3016(92)90768-d
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发表时间：
1992-01-01
影响因子：
7
通讯作者：
LINDSTROM, MJ
中科院分区：
文献类型：
--
作者：
FOWLER, JF;LINDSTROM, MJ
已审查了12项已发表的头颈癌根治性放疗的临床结果，其中7项进行了新的多变量分析，以确定将局部控制与总体时间相关的时间因素的大小。 除两个数据集外，所有数据集均观察到局部控制显著丧失，且延长。 仅在1周内的中位丢失率为14%，范围为3%至25%。 这相当于2周内的中位损失为26%（5-42%）。 这些结果与其他不太详细的信息具有可比性。 无论这些显著的损失是由于肿瘤细胞的增殖还是由于其他原因，如医生的选择，很明显，适度的延长与局部控制的机会较低有关。
Twelve published clinical results of radical radiotherapy of head and neck cancer have been reviewed, seven of them with fresh multivariate analyses, to determine the magnitude of time factors relating local control to overall time. In all but two of the data sets a significant loss of local control was observed with prolongation. The median rate of loss was 14% in only 1 week, the range 3 to 25%. This corresponds to a median loss of 26% in 2 weeks (5-42%). These results are comparable with other, less detailed information. Whether these significant losses are due to proliferation of tumor cells or to other causes such as physician selection, it is clear that modest prolongation is associated with a lower chance of local control.