Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction
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DOI：
10.1364/ao.44.001858
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发表时间：
2005-04-01
期刊：
影响因子：
1.9
通讯作者：
Paulsen, KD
中科院分区：
文献类型：
--
作者：
Srinivasan, S;Pogue, BW;Paulsen, KD
在近红外频域层析成像中实现了一种多光谱直接生色团和散射重建技术，用于恢复总血红蛋白、血氧饱和度、水分和散射参数的图像。该方法将生色团光谱约束和散射光谱约束直接应用到重建算法中，从而减少了反演过程的参数空间。利用仿真和实验数据对该方法进行了验证，结果表明，该方法在较高的噪声水平下具有较好的鲁棒性和稳定性。该方法抑制了伪影，特别是在水和散射能量图像中明显存在的伪影，并减少了生色团和散射参数之间的串扰。在直径90 mm的圆柱体模的实验数据中，这种光谱方法成功地跟踪了散射的变化，结果表明，散射幅度和折合散射系数(mU(S)‘)呈线性变化，总血红蛋白、血氧饱和度和水分保持恒定和定量准确。对于不同的血氧饱和度和总血红蛋白也进行了类似的实验。定量准确，血氧饱和度的平均误差为7.7%，总血红蛋白的平均误差为6.2%，不同参数之间的串扰最小。(C)2005年美国光学学会。
A multispectral direct chromophore and scattering reconstruction technique has been implemented for near-infrared frequency-domain tomography in recovering images of total hemoglobin, oxygen saturation, water, and scatter parameters. The method applies the spectral constraint of the chromophores and scattering spectra directly in the reconstruction algorithm, thereby reducing the parameter space of the inversion process. This new method was validated by use of simulated and experimental data, and results show better robustness and stability in the presence of higher levels of noise. The method suppresses artifacts, especially those significant in water and scatter power images, and reduces cross talk between chromophore and scatter parameters. Variation in scattering was followed by this spectral approach successfully in experimental data from 90-mm-diameter cylindrical phantoms, and results show linear variation in scatter amplitude and reduced scattering coefficient (mu(s)'), with total hemoglobin, oxygen saturation, and water remaining constant and quantitatively accurate. Similar experiments were carried out for varying oxygen saturation and total hemoglobin. Accurate quantification was obtained with a mean error of 7.7% for oxygen saturation and 6.2% for total hemoglobin, with minimal cross talk between different parameters. (c) 2005 Optical Society of America.