Stilbenes from the leaves of Cajanus cajan and their in vitro anti-inflammatory activities
Stilbenes from the leaves of Cajanus cajan and their in vitro anti-inflammatory activities
复制标题
DOI：
10.1016/j.fitote.2022.105229
复制
发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Wu Zhen-Long
中科院分区：
文献类型：
--
作者：
Tan Ling-Xuan;Xia Tian-Qi;He Qi-Fang;Tang Wei;Huang Xiao-Jun;Song Qiao-Yun;Li Yao-Lan;Ye Wen-Cai;Wang Ying;Wu Zhen-Long
Eighteen stilbenes (1-18), including six previously undescribed ones (1-6), with diverse modification patterns were isolated from the leaves of edible and medicinal plant Cajanus cajan. Among the new isolates, compounds 1-3 were initially obtained as three racemic mixtures, which were further resolved into three pairs of optically pure enantiomers, respectively, by chiral HPLC. Besides, compounds 8, 10, 11, and 18 were obtained from C. cajan for the first time. The chemical structures and absolute configurations of the new stilbenes were elucidated unambiguously on the basis of extensive spectroscopic analyses, single crystal X-ray crystallographic study, and quantum chemical electronic circular dichroism (ECD) calculations. In addition, the in vitro anti-inflammatory activities of all isolated stilbenes were evaluated. Compounds 2, 9, 10, 11, and 14 exerted moderate suppression of nitric oxide (NO) secretion in lipopolysaccharide (LPS)-induced RAW264.7 cells without exhibiting substantial cytotoxicity.
