Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system
Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system
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DOI：
10.1016/s0960-9822(00)00713-2
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发表时间：
2000-10-05
期刊：
影响因子：
9.2
通讯作者：
Maffei, L
中科院分区：
文献类型：
--
作者：
Caleo, M;Menna, E;Maffei, L
背景：神经营养因子包括神经生长因子(NGF)、脑源性神经营养因子(BDNF)、神经营养因子-3(NT-3)、NT-4/5和NT-6，是一类在周围和中枢神经元的分化、存活和维持中起基础作用的蛋白质家族。许多研究都集中在神经营养因子作为靶向衍生的、逆行运输的营养分子的作用上。虽然最近有证据表明BDNF和NT-3可以沿外周和中枢轴突顺行运输，但尚未有确凿证据表明这些顺行因子具有直接的突触后作用。结果：我们报道了BDNF沿视神经顺行运输，顺行运输的BDNF对大脑上丘和外侧膝状核中的视网膜靶神经元有快速作用。当发育中的上丘内的内源性BDNF被中和时，程序性神经元死亡的比率增加。结论：视网膜神经节细胞释放的BDNF是视网膜靶区突触后神经元的生存因子。(C)2000爱思唯尔科学有限公司。保留所有权利。
Background: The neurotrophins, which include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) neurotrophin-3 (NT-3), NT-4/5 and NT-6, are a family of proteins that play fundamental roles in the differentiation, survival and maintenance of peripheral and central neurons. Much research has focused on the role of neurotrophins as target-derived, retrogradely transported trophic molecules. Although there is recent evidence that BDNF and NT-3 can be transported in an anterograde direction along peripheral and central axons, there is as yet no conclusive evidence that these anterograde factors have direct post-synaptic actions,Results: We report that BDNF travels in an anterograde direction along the optic nerve, The anterogradely transported BDNF had rapid effects on retinal target neurons in the superior colliculus and lateral geniculate nucleus of the brain. When endogenous BDNF within the developing superior colliculus was neutralised, the rate of programmed neuronal death increased. Conversely, provision of an afferent supply of BDNF prevented the degeneration of geniculate neurons after removal of their cortical target.Conclusions: BDNF released from retinal ganglion cells acts as a survival factor for post-synaptic neurons in retinal target fields. (C) 2000 Elsevier Science Ltd. All rights reserved.