Factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an Ontario cohort of grade 8 girls.
Factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an Ontario cohort of grade 8 girls.
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DOI：
10.1186/1471-2458-11-645
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发表时间：
2011-08-13
影响因子：
4.5
通讯作者：
Lévesque LE
中科院分区：
文献类型：
--
作者：
Smith LM;Brassard P;Kwong JC;Deeks SL;Ellis AK;Lévesque LE
虽然已经投资了一亿多美元为安大略的年轻女孩提供免费的四价人乳头瘤病毒（HPV）疫苗接种，但关于其使用情况的信息仍然很少。为了成功地指导未来的HPV疫苗规划，重要的是要监测HPV疫苗的使用并确定与该人群使用相关的因素。通过连接行政卫生和免疫数据库，我们对金斯顿、弗伦特纳克、伦诺克斯和阿丁顿符合安大略8级HPV疫苗接种计划的女孩进行了一项基于人群的回顾性队列研究。我们确定了开始（至少一剂）和完成（所有三剂）疫苗接种系列的女孩的比例，并根据社会人口统计学，疫苗接种史，卫生服务利用，病史和计划年。多变量逻辑回归用于估计个体因素与启动和完成之间的关联强度，并对所有其他因素进行调整。我们确定了一个由2519名女孩组成的队列，其中56.6%至少接受了一剂HPV疫苗。在接种疫苗的女孩中，85.3%接受了所有三剂疫苗。接种疫苗史是最强的启动预测因子，因为接种麻疹-腮腺炎-风疹、脑膜炎球菌C和肝炎B疫苗的女孩更有可能同时接种HPV疫苗（比值比4.89; 95%置信区间4.04-5.92）。然而，HPV疫苗的接种率比其他疫苗低20%以上。此外，虽然系列启动不受收入的影响，系列完成。特别是，低收入的女孩最不可能接受所有三种指定剂量的HPV疫苗（比值比0.45; 95%置信区间0.28-0.72）。目前金斯顿、弗伦特纳克、伦诺克斯和阿丁顿的HPV疫苗接受率较低，这可能会对其公共资助项目的健康益处和成本效益产生重要影响。我们确定了与系列开始和完成相关的重要因素，这些因素应在努力改善该人群中HPV疫苗的使用时加以考虑。
Although over a hundred million dollars have been invested in offering free quadrivalent human papillomavirus (HPV) vaccination to young girls in Ontario, there continues to be very little information about its usage. In order to successfully guide future HPV vaccine programming, it is important to monitor HPV vaccine use and determine factors associated with use in this population. Linking administrative health and immunization databases, we conducted a population-based, retrospective cohort study of girls eligible for Ontario's Grade 8 HPV vaccination program in Kingston, Frontenac, Lennox, and Addington. We determined the proportion of girls who initiated (at least one dose) and completed (all three doses) the vaccination series overall and according to socio-demographics, vaccination history, health services utilization, medical history, and program year. Multivariable logistic regression was used to estimate the strength of association between individual factors and initiation and completion, adjusted for all other factors. We identified a cohort of 2519 girls, 56.6% of whom received at least one dose of the HPV vaccine. Among vaccinated girls, 85.3% received all three doses. Vaccination history was the strongest predictor of initiation in that girls who received the measles-mumps-rubella, meningococcal C, and hepatitis B vaccines were considerably more likely to also receive the HPV vaccine (odds ratio 4.89; 95% confidence interval 4.04-5.92). Nevertheless, HPV vaccine uptake was more than 20% lower than that of these other vaccines. In addition, while series initiation was not influenced by income, series completion was. In particular, girls of low income were the least likely to receive all three indicated doses of the HPV vaccine (odds ratio 0.45; 95% confidence interval 0.28-0.72). The current low level of HPV vaccine acceptance in Kingston, Frontenac, Lennox, and Addington will likely have important implications in terms of the health benefits and cost-effectiveness of its publicly funded program. We identified important factors associated with series initiation and completion that should be considered in efforts to improve HPV vaccine use in this population.
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影响因子：
6.4
作者：
Muñoz, N;Bosch, FX;Meijer, CJLM
通讯作者：
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影响因子：
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DOI：
10.1007/bf03405774
发表时间：
2004-03-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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