INDUCTION IN VITRO OF TRACHEAL BUDS BY PULMONARY MESENCHYME GRAFTED ON TRACHEAL EPITHELIUM
INDUCTION IN VITRO OF TRACHEAL BUDS BY PULMONARY MESENCHYME GRAFTED ON TRACHEAL EPITHELIUM
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DOI：
10.1002/jez.1401500202
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发表时间：
1962-01-01
影响因子：
--
通讯作者：
CASSINI, A
中科院分区：
文献类型：
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作者：
ALESCIO, T;CASSINI, A
通过将间充质移植到气管上皮来研究小鼠胚胎肺的支气管间充质的诱导作用。支气管间充质能够从气管上皮诱导出多余的芽。芽的形状和发育方式与正常支气管芽相似。结论是，在所研究的阶段，肺间质由诱导上皮出芽的支气管部分和不诱导上皮出芽的气管部分组成。另一方面，早期的气管上皮尚未完全确定，因为它能够在支气管间充质的作用下产生多余的芽。讨论了与肺树器官发生中上皮-间质相互作用的一般意义相关的结果。
The inductive action of bronchial mesenchyme of mouse embryonic lung was studied by means of grafts of this mesenchyme into tracheal epithelium. The bronchial mesenchyme is able to induce a supernumerary bud from tracheal epithelium. The shape and manner of development of the bud resemble those of normal bronchial buds. It is concluded that at the stage studied the pulmonary mesenchyme consists of a bronchial part which induces budding from epithelium and of a tracheal part which does not. The early tracheal epithelium on the other hand is not very fully determined, as it is capable of producing a supernumerary bud under the action of bronchial mesenchyme. The results are discussed in relation to the general meaning of epithelio-mesenchymal interaction in the organogenesis of the pulmonary tree.