Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept.
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept.
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DOI：
10.1586/epr.10.36
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发表时间：
2010-08
影响因子：
3.4
通讯作者：
Uversky VN
中科院分区：
文献类型：
--
作者：
Uversky VN
许多具有生物活性的蛋白质在体外生理条件下缺乏稳定的三级和/或二级结构，通常被称为内在无序或天然未折叠蛋白质。它们的功能补充了有序蛋白的功能库，而内在无序蛋白（IDP）通常参与调节，信号传导和控制。它们的氨基酸序列和组成与有序蛋白质的氨基酸序列和组成非常不同，使得在蛋白质组水平上可靠地鉴定IDP成为可能。IDP在各种人类疾病中非常丰富，包括神经变性和其他蛋白质功能障碍疾病，因此代表了有吸引力的新药物靶点。IDPs的一些方面，以及它们在神经变性和蛋白质功能障碍疾病中的作用，在本文中进行了讨论，连同IDPs作为潜在药物靶点的特性。
Many biologically active proteins, which are usually called intrinsically disordered or natively unfolded proteins, lack stable tertiary and/or secondary structure under physiological conditions in vitro. Their functions complement the functional repertoire of ordered proteins, with intrinsically disordered proteins (IDPs) often being involved in regulation, signaling and control. Their amino acid sequences and compositions are very different from those of ordered proteins, making reliable identification of IDPs possible at the proteome level. IDPs are highly abundant in various human diseases, including neurodegeneration and other protein dysfunction maladies and, therefore, represent attractive novel drug targets. Some of the aspects of IDPs, as well as their roles in neurodegeneration and protein dysfunction diseases, are discussed in this article, together with the peculiarities of IDPs as potential drug targets.
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
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