Wrist Circumference as a Novel Predictor of Diabetes and Prediabetes: Results of Cross-Sectional and 8.8-Year Follow-up Studies
Wrist Circumference as a Novel Predictor of Diabetes and Prediabetes: Results of Cross-Sectional and 8.8-Year Follow-up Studies
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DOI：
10.1210/jc.2012-2416
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发表时间：
2013-02-01
影响因子：
5.8
通讯作者：
Azizi, Fereidoun
中科院分区：
文献类型：
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作者：
Noudeh, Younes Jahangiri;Hadaegh, Farzad;Azizi, Fereidoun
目的：我们的目的是研究手腕周长是否与事件2型糖尿病，独立于一般（体重指数[BMI]）或中央（腰围[WC]）肥胖措施在伊朗成年population.Research设计和方法的队列：共有9330名受试者>= 20岁的横断面研究。对于前瞻性分析，排除了患有糖尿病的受试者，留下6393例受试者（2716例男性和3677例女性）。在基线和随访期间进行标准的攻毒后2小时血糖检测。考克斯回归分析被用来估计糖尿病的危险比手腕circumstance.Results：在平均随访8.8年，649例新发糖尿病发生。在基线时，使用线性回归模型，我们发现男性和女性的腕围与糖尿病危险因素之间存在显著的线性相关性，并且在控制了女性的BMI或WC后，这种相关性仍然显著。在前瞻性评估中，腕围与糖尿病发病率显著相关（男性和女性的多变量调整风险比分别为1.17 [1.03-1.32]和1.31 [1.18-1.45]）。在控制了受试者的BMI或WC后，腕围仅在女性中是糖尿病的独立预测因子。手腕周长是一个独立的预测代谢综合征的妇女，即使调整后的BMI，WC，或both.Conclusions：手腕周长是一个显着的预测糖尿病在两种性别的成年人。然而，其预测性是独立的BMI或WC只有在女性。由于其简单易测的性质，腕围可以被认为是预测2型糖尿病和代谢综合征的一种新的人体测量评估。（J Clin Endocrinol Metab 98：777-784，2013）
Objective: Our objective was to examine whether wrist circumference is associated with incident type 2 diabetes mellitus, independently of general (body mass index [BMI]) or central (waist circumference [WC]) adiposity measures in a cohort of an Iranian adult population.Research Design and Methods: A total of 9330 subjects >= 20 years of age were included in the cross-sectional study. For prospective analysis, subjects with prevalent diabetes were excluded, leaving 6393 subjects (2716 males and 3677 females). The standard 2-hour postchallenge plasma glucose test was performed at baseline and during follow-up. Cox regression analysis was used to estimate the hazard ratio of diabetes for wrist circumference.Results: During a mean follow-up of 8.8 years, 649 new cases of diabetes occurred. At baseline, using linear regression models, we showed significant linear associations between wrist circumference and diabetes risk factors in both genders, and this association remained significant after controlling for BMI or WC among females. In prospective evaluation, wrist circumference was significantly associated with incident diabetes (multivariable-adjusted hazard ratio = 1.17 [1.03-1.32] and 1.31 [1.18-1.45] for males and females, respectively). After controlling for the subjects' BMI or WC, wrist circumference was an independent predictor of diabetes only among females. Wrist circumference was an independent predictor of metabolic syndrome only among women even after adjustment for BMI, WC, or both.Conclusions: Wrist circumference is a significant predictor of diabetes in both genders of adult population. However, its predictability is independent of BMI or WC only among females. Because of its simple and easy-to-detect nature, wrist circumference could be considered as a new anthropometric assessment for prediction of type 2 diabetes and metabolic syndrome. (J Clin Endocrinol Metab 98: 777-784, 2013)