Does abnormal neuronal excitability exist in myotonic dystrophy)?¶I. Effects of the antiarrhythmic drug hydroquinidine on slow saccadic eye movements
Does abnormal neuronal excitability exist in myotonic dystrophy)?¶I. Effects of the antiarrhythmic drug hydroquinidine on slow saccadic eye movements
复制标题
强直性肌营养不良是否存在神经元兴奋性异常？¶I. 抗心律失常药物氢奎尼丁对慢眼跳的影响
作者：
A. Di Costanzo;A. Mottola;A. Toriello;G. Di Iorio;G. Tedeschi;V. Bonavita
摘要强直性肌营养不良（MD）的神经元兴奋性异常可能与MD患者的精神和行为障碍有关。为了获得对MD病理生理学的新见解，我们确定了抗抑郁药氢奎尼丁是否会改善MD患者的缓慢扫视眼动（SEMs）、冷漠和嗜睡。选择SEM作为心理调查的简单方式。本研究以随机、安慰剂对照、双盲、交叉方式进行。入选了10例无氢奎尼丁给药禁忌症的非卧床患者。口服氢奎尼丁（450 mg/天）或安慰剂6周，两次治疗之间有6周的洗脱期。扫描电镜记录的眼电图和计算机系统进行分析。两名患者在积极治疗的第一周因恶心和上腹痛而退出。与安慰剂相比，氢奎尼丁显著增加了标准化的峰值扫视速度，缩短了扫视反应时间。该药物对冷漠和嗜睡的影响在一篇配套论文中介绍。
Abstract The abnormal neuronal excitability hypothesized in myotonic dystrophy (MD) might contribute to psychomotor and behavioral disturbances of MD patients. To gain new insights into the pathophysiology of MD, we determined whether the antiarrhythmic drug hydroquinidine would ameliorate slow saccadic eye movements (SEMs), apathy and hypersomnia in MD patients. SEMs were selected as simple modality for psychomotor investigation. The study was conducted in a randomized placebo-controlled, double-blind, crossover manner. Ten ambulatory patients without contraindications to hydroquinidine administration were enrolled. Hydroquinidine (450 mg/day) or placebo was given orally for 6 weeks with a washout period of 6 weeks between treatments. SEMs were recorded by electrooculography and analyzed by a computer system. Two patients withdrew in the first week of active treatment because of nausea and epigastralgia. Hydroquinidine significantly increased the normalized peak saccadic velocity and shortened the saccadic reaction time compared to placebo. The drug's effects on apathy and hypersomnia are presented in a companion paper.