Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue
Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue
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DOI：
10.1098/rsta.2016.0289
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发表时间：
2017-05-17
期刊：
影响因子：
5
通讯作者：
Parlitz, U.
中科院分区：
文献类型：
--
作者：
Boccia, E.;Luther, S.;Parlitz, U.
在心脏组织中，钉扎到异质性的电螺旋波可以使用电远场脉冲并将异质性募集为虚拟电极来解除钉扎（并最终终止）。虽然对于各向同性介质，解钉扎的过程要好得多，但在不同方向上具有不同电导率的各向异性衬底的情况仍需要深入研究。为了研究各向异性的影响的unpinning过程中，我们提出了数值模拟的基础上的bidomain制定的阶段I的Luo和鲁迪动作电位模型修改由于急性心肌缺血的发生。模拟旋转螺旋波钉到一个缺血的异质性，我们比较成功的序列的远场脉冲的各向同性和各向异性的情况下，螺旋仍然在瞬态或稳定的旋转状态。我们的研究结果清楚地表明，成功终止钉扎螺旋波的起搏参数的范围是各向异性组织比在各向同性medium.This文章的主题问题的一部分“数学方法在医学：神经科学，心脏病学和病理学”。
In cardiac tissue, electrical spiral waves pinned to a heterogeneity can be unpinned (and eventually terminated) using electric far field pulses and recruiting the heterogeneity as a virtual electrode. While for isotropic media the process of unpinning is much better understood, the case of an anisotropic substrate with different conductivities in different directions still needs intensive investigation. To study the impact of anisotropy on the unpinning process, we present numerical simulations based on the bidomain formulation of the phase I of the Luo and Rudy action potential model modified due to the occurrence of acute myocardial ischaemia. Simulating a rotating spiral wave pinned to an ischaemic heterogeneity, we compare the success of sequences of far field pulses in the isotropic and the anisotropic case for spirals still in transient or in steady rotation states. Our results clearly indicate that the range of pacing parameters resulting in successful termination of pinned spiral waves is larger in anisotropic tissue than in an isotropic medium.This article is part of the themed issue 'Mathematical methods in medicine: neuroscience, cardiology and pathology'.