Hyperthermia: a potent enhancer of radiotherapy
Hyperthermia: a potent enhancer of radiotherapy
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DOI：
10.1016/j.clon.2007.03.015
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发表时间：
2007-08-01
影响因子：
3.4
通讯作者：
Overgaard, J.
中科院分区：
文献类型：
--
作者：
Horsman, M. R.;Overgaard, J.
热疗通常被认为是一种实验性的治疗方法，在临床癌症治疗中没有现实的前景。这是完全错误的。虽然单独的热疗作为癌症治疗的作用可能是有限的，但有大量的临床前数据表明，与辐射相结合，它是已知的最有效的辐射增敏剂之一。此外，在各种肿瘤类型中进行的大量随机临床试验清楚地表明，热疗有可能显着改善局部肿瘤控制和放射治疗后的生存率，而不会显着增加副作用。在这里，我们回顾了临床前的基本原理结合热疗与辐射，并总结了临床数据显示其疗效。
Hyperthermia is generally regarded as an experimental treatment with no realistic future in clinical cancer therapy. This is totally wrong. Although the role of hyperthermia alone as a cancer treatment may be limited, there is extensive preclinical data showing that in combination with radiation it is one of the most effective radiation sensitisers known. Moreover, there are a number of large randomised clinical trials in a variety of tumour types that clearly show the potential of hyperthermia to significantly improve both local tumour control and survival after radiation therapy, without a significant increase in side-effects. Here we review the pre-clinical rationale for combining hyperthermia with radiation, and summarise the clinical data showing its efficacy.