COVID-19 in HIV: a Review of Published Case Reports.
COVID-19 in HIV: a Review of Published Case Reports.
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DOI：
10.1007/s42399-020-00593-6
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Desai R
中科院分区：
文献类型：
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作者：
Morani Z;Patel S;Ghosh S;Hassan FA;Doreswamy S;Singh S;Kothapudi VN;Desai R
COVID-19患者存在多种合并症。COVID-19患者的免疫功能低下状态（如HIV）可能危及生命。我们在PubMed/Medline、Scopus和Web of Science中检索了关于HIV患者中COVID-19的病例报告和病例系列。我们最终审查了20份病例报告，包括43例HIV和COVID-19患者的病例。43例成人患者的平均年龄为51.56 ± 27.56岁（范围24-76岁）。其中，男性30人（69.77%），女性11人（25.58%），变性人2人（4.65%）。50岁以上患者25例（58.14%）。最常见的心血管合并症为高血压和高脂血症（48.8%）、糖尿病（20.93%）和病态肥胖（11.63%）。在43名感染COVID-19的HIV患者中，6人死亡（13.95%）。死亡患者均为50岁以上老年人，需机械通气。感染COVID-19的HIV患者死亡率很高。这些患者既存合并症的高负担和高龄使其易于疾病进展和更差的结局。
Patients with COVID-19 present with a myriad of comorbidities. An immunocompromised state like HIV in patients with COVID-19 can be life-threatening. We searched PubMed/Medline, Scopus, and Web of Science for case reports and case series about COVID-19 in HIV patients. We finally reviewed 20 case reports including cases of 43 patients with HIV and COVID-19. The mean age of 43 adult patients was 51.56 ± 27.56 years (range 24–76 years). Of these, 30 were male (69.77%), 11 were female (25.58%), and 2 were transgender (4.65%). A total of 25 patients (58.14%) were above 50 years of age. The most common cardiovascular comorbidities were hypertension and hyperlipidemia (48.8%), diabetes (20.93%), and morbid obesity (11.63%). Out of 43 HIV patients with COVID-19, 6 resulted in death (13.95%). All the patients who died were elderly above 50 years and required mechanical ventilation. HIV patients infected with COVID-19 had a high mortality rate. A high burden of pre-existing comorbidities and an advanced age in these patients make them prone to disease progression and worse outcomes.