Cardiovascular response to vasopressin vasopressor antagonist administration during water deprivation in the rat.
Cardiovascular response to vasopressin vasopressor antagonist administration during water deprivation in the rat.
复制标题
大鼠缺水期间对加压素加压剂拮抗剂给药的心血管反应。
DOI：
10.1159/000123881
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发表时间：
1984
影响因子：
4.1
通讯作者：
Brooks,DP
中科院分区：
文献类型：
--
作者：
Rockhold,RW;Share,L;Crofton,JT;Brooks,DP
在清醒大鼠的基础条件下和脱水48 h后，研究了脑室内和静脉注射选择性血管加压素拮抗剂[1-(β-巯基β， β-环五亚甲基丙酸-2-（0-甲基）酪氨酸]精氨酸血管加压素（TMe-AVP）对心血管的影响。静脉滴注抗利尿激素（50 ng/kg）的加压反应未因用载药或0.5µg/kg TMe-AVP进行静脉滴注而减弱。5.0µg/kg TMe-AVP （i.c.v.）剂量确实降低了抗利尿激素的降压反应，表明拮抗剂外周渗漏。缺水48小时后，抗利尿激素血浆浓度从0.7±0.1µU/ml增加到2.8±0.1µU/ml，血压从112±2升高到123±1 mmhg。在缺水动物中，静脉滴注（0.5µg/kg）或静脉滴注（5.0µg/kg）均未检测到抗利尿激素拮抗剂对血压的影响。然而，在静脉注射5.0µg/kg TMe-AVP后，观察到缺水大鼠心率显著增加。中枢抗利尿激素-抗利尿激素受体阻断似乎对基础条件下或缺水期间的血压几乎没有影响。这些数据进一步描述了血浆加压素浓度与心血管稳态的关系。
The cardiovascular effects of intracerebroventricular (i.c.v.) and intravenous (i.v.) injection of a selective vasopressin vasopressor antagonist, [1-(β-mercapto-β, β-cyclopentamethylenepropionic acid-2-(0-methyl)tyrosine]arginine vasopressin (TMe-AVP) were examined in conscious rats under basal conditions and following 48 h of water deprivation. Pressor responses to i.v. vasopressin (50 ng/kg) were not blunted by i.c.v. treatment with either vehicle or 0.5 µg/kg TMe-AVP. A dose of 5.0 µg/kg TMe-AVP (i.c.v.) did reduce the pressor response to vasopressin, indicating peripheral leakage of the antagonist. Water deprivation for 48 h increased plasma vasopressin concentrations from 0.7 ± 0.1 to 2.8 ± 0.1 µU/ml and increased blood pressure from 112 ± 2 to 123 ± 1 mm Hg. No effect of the vasopressin antagonist on blood pressure could be detected following either i.c.v. (0.5 µg/kg) or i.v. (5.0 µg/kg) treatment in water-deprived animals. However, a significant increase in heart rate was observed in water-deprived rats following i.v. injection of 5.0 µg/kg of TMe-AVP. Central vasopressin vasopressor receptor blockade appears to exert little effect on blood pressure either under basal conditions or during water deprivation. The data further delineate the relationship of plasma vasopressin concentrations to cardiovascular homeostasis.