Axon growth and guidance: receptor regulation and signal transduction.
Axon growth and guidance: receptor regulation and signal transduction.
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DOI：
10.1146/annurev.neuro.051508.135614
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发表时间：
2009
影响因子：
13.9
通讯作者：
Bashaw GJ
中科院分区：
文献类型：
--
作者：
O'Donnell M;Chance RK;Bashaw GJ
在神经系统建立过程中，精确连接模式的发展取决于不同的、保守的引导信号家族及其神经元受体的调节作用。确定这些信号通路如何调节轴突生长和指导对于理解神经系统中的布线特异性至关重要，并且无疑将揭示许多神经发育障碍。已经取得了相当大的进展，在定义的机制，调节正确的空间和时间分布的指导受体，以及这些受体如何反过来信号的生长锥细胞骨架，以控制转向的决定。本文综述了近年来在生长锥导向调控机制方面的研究进展，特别强调了导向受体的调控和信号传导。
The development of precise connectivity patterns during the establishment of the nervous system depends on the regulated action of diverse, conserved families of guidance cues and their neuronal receptors. Determining how these signaling pathways function to regulate axon growth and guidance is fundamentally important to understanding wiring specificity in the nervous system and will undoubtedly shed light on many neural developmental disorders. Considerable progress has been made in defining the mechanisms that regulate the correct spatial and temporal distribution of guidance receptors and how these receptors in turn signal to the growth cone cytoskeleton to control steering decisions. This review focuses on recent advances in our understanding of the mechanisms mediating growth cone guidance with a particular emphasis on the control of guidance receptor regulation and signaling.