Meiotic DSB patterning: A multifaceted process.
Meiotic DSB patterning: A multifaceted process.
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DOI：
10.1080/15384101.2015.1093709
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Neale MJ
中科院分区：
文献类型：
--
作者：
Cooper TJ;Garcia V;Neale MJ
减数分裂是一种特殊的两步细胞分裂，负责基因组单倍体化和配子体发生过程中遗传多样性的产生。减数分裂程序的一个完整而独特的特征是进化上保守的同源重组（HR）的起始，通过发育程序化的诱导DNA双链断裂（DSBs）。DSB形成的本质上是危险的，但却是必要的行为，它受到多种形式的严格和自我纠正的调节，这些调节共同确保了富有成效和适当水平的基因交换，而不会危及细胞生存。在本文中，我们将重点关注这种控制空间调控的一个新兴元素，详细介绍了在理解dsb如何均匀分布在整个基因组方面取得的最新进展，并对所采用的潜在模式机制提出了统一的看法。
Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control—spatial regulation—detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.
影响因子：
3
作者：
Champeimont R;Carbone A
通讯作者：
Carbone A