Serotonin regulation of tachykinin biosynthesis in the rat neostriatum.
Serotonin regulation of tachykinin biosynthesis in the rat neostriatum.
复制标题
大鼠新纹状体中速激肽生物合成的血清素调节。
DOI：
10.1016/0006-8993(91)91155-t
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Jonakait,GM
中科院分区：
文献类型：
--
作者：
Walker,PD;Riley,LA;Hart,RP;Jonakait,GM
Serotonin (5-HT) neurotransmission was altered to determine its role in regulating the biosynthesis of tachykinins in the neostriatum (NS). Depletion of 5-HT with subchronicp-chlorophenylalanine> (pCPA) treatment decreased preprotachykinin (PPT, the prohormone precursor to SP) mRNA levels in the NS. By contrast, raising extracellular 5-HT levels with zimelidine (a 5-HT uptake inhibitor) or clorgyline (a monoamine oxidase inhibitor) resulted in increased levels of PPT mRNA. To determine whether 5-HT receptors played a role in mediating the changes in PPT mRNA, animals were treated with the 5-HT2agonist DOI. This drug significantly increased both PPT mRNA and SP-like immunoreactivity in the NS. These results together indicate that neostriatal tachykinin biosynthesis is sensitive to alterations in 5-HT neurotransmission.
