Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents
Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents
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DOI：
10.1021/np070383f
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发表时间：
2007-12-01
影响因子：
5.1
通讯作者：
Wu, Tian-Shung
中科院分区：
文献类型：
--
作者：
Kuo, Ping-Chung;Shen, Yuh-Chiang;Wu, Tian-Shung
对越南巴豆的甲醇提取物进行细胞毒性引导的植物化学研究，得到两种新的贝壳杉烷型二萜（1，2）和10种已知的对映贝壳杉烷型二萜（3-12）。I和2的结构基于光谱和质谱数据的分析。化合物3-12通过与文献报道的光谱和物理数据的比较来鉴定。从这种植物中选择的化合物进行了细胞毒性和抗炎活性的检查。化合物4和9显示出对测试的肿瘤细胞系的最高细胞毒活性。化合物3、4、6、8、9和11的IC 50值小于5 μ M，并且在抑制LPS诱导的NO产生方面比非特异性NOS抑制剂L-NAME更有效。
Cytotoxicity-guided phytochemical investigation of a methanolic extract of Croton tonkinensis afforded two new kaurane diterpenoids (1, 2) and 10 known ent-kaurane-type diterpenoids (3-12). The structures of I and 2 were based on analysis of spectroscopic and mass spectral data. Compounds 3-12 were identified by comparison of their spectroscopic and physical data with those reported in the literature. Selected compounds from this plant were examined for cytotoxic and anti-inflammatory activities. Compounds 4 and 9 showed the highest cytotoxic activity against the tested tumor cell lines. Compounds 3, 4, 6, 8, 9, and 11 had IC50 values less than 5 mu M and were more potent than the nonspecific NOS inhibitor L-NAME in inhibiting LPS-induced NO production.