Noninvasive measurement of pulsatile intracranial pressure using ultrasound.
Noninvasive measurement of pulsatile intracranial pressure using ultrasound.
复制标题
使用超声波无创测量脉动颅内压。
DOI：
10.1007/978-3-7091-6475-4_21
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Hargens
中科院分区：
文献类型：
--
作者：
T. Ueno;R. Ballard;L. Shuer;J. Cantrell;W. Yost;A. Hargens
本研究旨在验证我们的无创超声技术（脉冲锁相环：PPLL）测量颅内压（ICP）波形。该技术基于检测已知与颅内压改变一起发生的颅骨运动。在台架模型研究中，PPLL输出与换能器和反射目标之间的距离变化高度相关（R2 = 0.977）。在尸体研究中，测量经颅距离，同时通过有节奏地注射生理盐水产生ICP脉动（振幅为0至10 mmHg）。频率分析（快速傅立叶变换）清楚地表明PPLL输出和ICP脉冲周期之间的对应关系。尽管理论上PPLL输出的变化有微小的可能性是由脑组织的超声速度的变化引起的，但是随着头部的外部压缩增加，PPLL输出的幅度减小表明PPLL输出代表与改变的ICP相关的实质性颅骨移动。总之，超声设备具有足够的灵敏度来检测与心动周期相关的经颅脉动。我们的技术使无创分析ICP波形成为可能，并将有助于了解颅内顺应性和脑血管循环。
The present study was designed to validate our noninvasive ultrasonic technique (pulse phase locked loop: PPLL) for measuring intracranial pressure (ICP) waveforms. The technique is based upon detecting skull movements which are known to occur in conjunction with altered intracranial pressure. In bench model studies, PPLL output was highly correlated with changes in the distance between a transducer and a reflecting target (R2 = 0.977). In cadaver studies, transcranial distance was measured while pulsations of ICP (amplitudes of zero to 10 mmHg) were generated by rhythmic injections of saline. Frequency analyses (fast Fourier transformation) clearly demonstrate the correspondence between the PPLL output and ICP pulse cycles. Although theoretically there is a slight possibility that changes in the PPLL output are caused by changes in the ultrasonic velocity of brain tissue, the decreased amplitudes of the PPLL output as the external compression of the head was increased indicates that the PPLL output represents substantial skull movement associated with altered ICP. In conclusion, the ultrasound device has sufficient sensitivity to detect transcranial pulsations which occur in association with the cardiac cycle. Our technique makes it possible to analyze ICP waveforms noninvasively and will be helpful for understanding intracranial compliance and cerebrovascular circulation.